Numbers of people older than 50 years of age living with HIV (PWH) are increasing globally due to the success of combination antiretroviral therapy (cART). It is widely believed that HIV+ persons age at a faster pace than HIV uninfected, and prematurely develop non-AIDS related comorbidities. This symposium will discuss the basic science of inflammation, metabolism and epigenetics in aging in the context of HIV, the translational potential of senolytics in aging PWH, and impact of COVID19 on this population. Panelists will also discuss the role metabolic-epigenetic cross talk in the process of aging in HIV. By engaging experts and young minds together we expect that this symposium will help early stage investigators in their career development and professional growth.